Results of clinical studies :

• +20.3% Collagen VII, +15.8% Collagen XVII, +34% Collagen I, +19% Fibronectin 
• -29.4% reduction in wrinkle length after 2 months
• +42,2% hydration (1% high molecular weight non-cross-linked Hyaluronic Acid)
• -33% reduction in melanin synthesis (pigment responsible for spots) after 5 days of treatment (1% Dioic Acid + 5% Grade S Niacinamide)
• x4 more of our retinol encapsulated in the skin than conventional retinol. Its gradual activation prevents redness and flaking.

Use test carried out over 28 days:

• Skin is firmer = 96%
• Immediate tightening effect = 84%

3% Matrikines peptides

Peptides are proteins made up of amino acids which our body uses to repair, protect or regenerate cells. If the skin's elastin or collagen is damaged, Peptides, like all-important messengers, will tell the skin tissue to produce more of them. A young metabolic system naturally produces these peptides at the right moment; but with time and environmental oxidation, these chemical messengers slow down their activity, and the body struggles to regenerate itself. For fill wrinkles and provide a lifting effect we have chosen biomimetic Matrikine Peptides (as they mimic the repair mechanisms of native cells). At a dosage of 3%, they stimulate the synthesis of extracellular matrix macro-molecules (Collagen, Fibronectin, Hyaluronic Acid, etc.), fill in wrinkles and restructure the skin's mesh for renewed firmness.

2% Encapsulated and stabilized vitamin C

Vitamin C is a powerful antioxidant, with anti-wrinkle and anti-wrinkle and skin-lightening properties. Unfortunately, it degrades at the slightest contact with light and air, and becomes inactive. We have therefore chosen an encapsulated Vitamin C which, although highly technical and difficult to produce (hence its rarity), will be stabilized, protected from air and light to enable it to retain its full efficacy. Its gradual release into the skin's deeper layers enhances tolerance and considerably amplifies results compared with conventional Vitamin C.

5% Niacinamide Grade S

We have chosen a pure, powdered Grade S Niacinamide for maximum concentration and tolerance for sensitive skin. Grade S ensures a Niacinamide concentrated in Nicotinamide, the active part of the molecule. It contains no Nicotinic Acid, which is the irritant in conventional Niacinamides. 

As well as being extremely well-tolerated, the results on the skin are remarkable: collagen and elastin are boosted for firmer skin, while melanin transfer is reduced to minimize the appearance of pigmentation spots.

1% Encapsulated Retinol

We have chosen to use Encapsulated Retinol because of its many technical advantages:

In the dermis, this encapsulated Retinol stimulates Hyaluronic Acid synthesis and strengthens fibroblasts to promote collagen and elastin production, improving skin elasticity.

In addition, Retinol improves epidermal proliferation and differentiation, effectively reducing pigmentation spots and wrinkles.

1% Non-cross-linked high molecular weight hyaluronic acid

We have chosen a pure, powdered (=maximum concentration), non-cross-linked, high-molecular-weight Hyaluronic Acid.

Why not cross-linked? Because its molecules are not linked to each other, and are therefore free to spread evenly throughout the epidermis. Its molecular weight of 1000 Kda enables it to bind water (up to 1000 times its weight in water) for an immediate plumping effect, while reinforcing the cutaneous barrier and limiting Water Loss. 

Results: a significant reduction in the appearance of fine lines and wrinkles, smooth, plump skin.

1% Dioic acid

We use pure Dioic Acid powder to ensure maximum concentration, without preservatives. It is obtained by biofermentation of natural oleic acid, reinforcing its quality. This Dioic Acid has a powerful anti-spot effect by inhibiting tyrosinase responsible for melanin production. It regulates cell renewal promoting the elimination of pigmented cells and diminishing existing spots. Its antioxidant properties neutralize free radicals, reducing skin damage and blemishes. It also has an anti-inflammatory action to soothe inflammatory skin responses linked to pigmentation.

Advice from Dr Nicolas B.

Mesotherapy, also known as poly-vitamin injections, is a fast, effective aesthetic medicine treatment that involves injecting non-crosslinked hyaluronic acid, vitamins and essential active ingredients into the skin to boost elasticity, improve hydration and even out skin tone. My inspiration inspired by mesotherapy sessions to formulate this Serum Intense Nuit: Peptides matrikines, encapsulated Vitamin C, encapsulated Retinol, non-cross-linked Hyaluronic Acid, Niacinamide Grade S, Dioic Acide... all powerful ingredients, in high doses, to further even out skin tone and stimulate firmness at home. And if I've chosen a Night application, it's to capitalize on this period of intense cellular activity and revitalize your skin in depth. After applying the Intense Night Serum, apply the Intense Night Cream to accelerate the penetration of active ingredients and double the doses of Niacinamide Grade S, Encapsulated Retinol, Hyaluronic and Dioic Acids...the results will be even more striking!

MAKE YOUR PERSONALIZED DIAGNOSIS

Take a small amount of product equivalent to the length of your first distal phalanx (the one with your nail). Emulsify the product between your hands before applying it all over the face, pressing with your palms from the inside out. Reapply to emphasize the neck and décolleté areas.